Ziran Sha Pei deals artistically with ableism, queer feminism, racism and right-wing extremism in Western, Muslim and East Asian culture. In 2021, the artist founded the AStA anti-discrimination department at the Kunstakademie Düsseldorf and was one of the first people to actively campaign for equality issues in the educational institution with projects. 

As a descendant of resistance fighters from a Muslim minority in China who survived the war crimes of the Japanese Unit 731 during the Second World War, Ziran Sha Pei tries to convey the family's memories and historical testimonies artistically and didactically in painting and video installations. As part of an artistic research on migration, Ziran Pei Sha walked thousands of kilometers of the historic Silk Road as a solo traveler from 2013 to 2016.